New publication in Angewandte Chemie International Edition!

🔬 Title: Regioselective Hydrocyanation of Internal Alkynes Enabled by a Transition-Metal-Free Dual-Catalytic System
👥 Authors: A. Zasada, D. Lichosyt*
🔗 Read the article: https://doi.org/10.1002/anie.202500940
🧪 Preprint version: https://doi.org/10.26434/chemrxiv-2025-qhvvj

In this work, we report a transition-metal-free, highly regioselective hydrocyanation of internal alkynes using a dual-catalytic system, featuring:
✅ Broad substrate scope: 40 vinyl nitriles, including complex natural product derivatives
✅ Yields up to 97% and Z/E selectivity up to 20:1
✅ ~2500× cost reduction vs traditional TM-based methods
✅ Regioselectivity switch via catalyst modification (8 examples)
✅ Synthetic applications and mechanistic insight

🙏 This research was supported by the National Science Centre (NCN, Poland) under SONATA 16, no. 2020/39/D/ST4/01152.

👏 Congratulations to Ola Zasada on her first PhD publication!